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[2024-02] Asociations of MMP-9 with Environmental Factors and Disease Conditions

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  • 날짜 2024.02.26
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[2024-02] Asociations of MMP-9 with Environmental Factors and Disease Conditions
 
 
Hokyun Kim1
Moon Soul Graduate School of Future Strategy, KAIST
 
JooyoungJeon1*
Moon Soul Graduate School of Future Strategy, KAIST
 
JihoCha1
Moon Soul Graduate School of Future Strategy, KAIST
 
DongheeLim2
Samsung Medical Center, Seoul, South Korea
 
Yeo-kyungWon2
2Samsung Medical Center, Seoul, South Korea
 
  
Abstract
This study delves into the multifaceted associations between Matrix Metalloproteinase-9 (MMP-9) and a comprehensive array of environmental factors and disease conditions. MMP-9, known for its critical role in extracellular matrix remodeling and inflammation, has been implicated in various physiological and pathological processes. Our observational study, conducted with a substantial cohort from Samsung Medical Center, investigates the influences of air quality indicators, meteorological parameters, demographic factors, and a broad spectrum of disease conditions on MMP-9 levels. Using multivariate regression analysis, we explore the strength and direction of these associations, revealing significant links between MMP-9 and variables such as ozone levels, particulate matter, age, and specific health conditions like Diabetes Mellitus, Heart Failure, and Atherosclerosis. Our findings offer valuable insights into internal factors influencing MMP-9 expression, suggesting its potential as a biomarker for various pathological conditions. The non-invasive nature of MMP-9 measurement through tears underscores the convenience and applicability of this biomarker in clinical diagnostics and personalized medicine.
 
Keywords
Matrix Metalloproteinase-9 (MMP-9), Environmental Factors, Disease Conditions, Multivariate Regression Analysis, Biomarker
 
 

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